You can give it a try, but for some ukes it doesn't work very well. The main problem is probably string tension.
I have tried Worth low-G and that was very twangy on a soprano. The Extra Hard (thicker than regular) did work, but string tension was quite hard (go figure). While nice as a novelty, I will just use low tuning on concert and tenor models. The extra sustain and volume just sound better, where the soprano had too little oomph to work well.
Just my personal experience, you can also just try it for yourself. You may have to widen your bridge/nut slots a bit though, so consider well before you jump in.
Low G: the G note below your C string. 5th fret on G is your third string C note.