This tuning will put stronger pulling on the bridge, right? If so, is it possible that (a) some bridges might fail and/or (b) the top wood might be pulled out of shape?
Well, of course not all ukes are created equally so possibly yes.
I had the Aquila 30U strings installed on a cheap $30 Melokia soprano I got from Amazon (hard to find a budget soprano with 16 frets, which the Melokia has).
As one might imagine it needed extensive setup work, notwithstanding, the bridge was in fact both glued to the top, as well as screwed down with 2 screws, and I had the strings on for a few months, and during that time never saw any bellying/dishing from bridge rotation, nor lifting of the bridge.
I think the string tension would balance out, since strings 4 and 3, G and D respectively are wound and relatively low tension at soprano scale length, the A string (#2 string) was as one would expect, and the E string was higher tension of course but methinks it broke because it is supremely thin, and not necessarily from excessive tension.
My intent was to verify if I would like the sound up in that register if I was willing to butcher my hands with steel strings and invest in a mandolin (having become very fond of fifths tunings), and in the end, I decided that I could not really invest ~$250 USD for a decent starter mando at that time. Sure you can get cheaper mandos like a Rogue or Rondo for $49, but as the saying goes 'buy cheap, buy twice' and my intent is as a songwriting tool and do not want to start collecting mandolins as I climb up the ladder upgrading to better instruments...
Instead I now have about half my ukes in fifths tunings, tenors in re-entrant CGDA, baris in re-entrant GDAE, as well as a 22" scale steel string tenor guitar in re-entrant GDAE, and a 25" scale classical guitar that I've restrung and modified to be in CGDAE, like a 5-string octave mandolin...
I dunno what happened that caused me to digress...anyway...fifths tunings are lots of fun and can add another sound color to a ukulele strung/tuned this way...