I have a Jupiter Creek baritone and Risa tenor, both solid-body steel-string ukes. I play them through a couple of amps - a JS8 eBand for one - and often crank the drive up, or use an amp sim that has fuzz or distortion built in. Reverb, echo, chorus, flange, delay - use all the effects. Sounds great. Not at all uke-ish, though, sounds just like an electric guitar. But when you want to play the blues, there's nothing like a bit of overdrive to make it dirty.