If you mean a 'Mandolin' as in eight steel ( or even nylon) strings in four courses then definitely not. The poor thing would collapse under the tension.
If you just want a uke with mandolin tuning then Aquilla do strings if 'fifths' to give the standard mandolin/fiddle tuning of GDAE. I have two ukes fitted with these for when I play in a folk band as it makes all the standard tunes fall easily under the fingers and gives you a far greater range that standard uke tuning.
I believe they also do a set in fifths for a concert scale uke giving CGDA.