These are completely different voicings. I would prefer 1X02 if I want a B on top, 444X if I want a G# on top and 140X or 4447 if I want an E on top. (I have a low G in my hands while I'm writing this.)
A ukulele can work well as a blues instrument. I play the uke for some blues tunes in a jug band with a fiddle, guitar and washboard (sometimes a trombone, banjo and mouth harp). I've used both a plugged in uke and a reso-uke without a pick-up and they work well.
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