Thank you so much, guys, for all of your thoughts. To be honest, I'm a non-reader, and I pretty much do solo outings (with uke and voice), so whether I tune downward a step, or upward a step (from "standard"), I still play the same chord shapes that I would use in standard. In the first situation, my singing will therefore be in a lower range; in the second situation, my singing will be in a higher range and will require a little more effort-- but my chord formations on the uke won't be any different. I guess I'm lucky that I'm able to manage the variations in vocal range without too much trouble. I tend to get infatuated with a different tuning every couple of weeks. I'll be fine with "g C E A" for a while, and then I'll get the bug to go up to "a D F# B"; and soon I'll decide to relax things down to "f Bb D G" for that more laid back vibe. But in all of those situations, I'll use the same chord shapes across the board, regardless of which of the 3 tunings I'm using.