This question made me realize that of the 5 customs I've had done, they were only for look, not at all for sound. I find that my 9 ukes, custom or off the shelf, are so close in sound and playability, that the look is what differentiates them.
The first custom I had done 7 years ago was a gypsy jazz style all solid, flame maple top, Indian rosewood body. When I first played it, I thought it didn't have the projection or sustain I wanted, but after about 18 months, it opened up and now it sounds great.
The most recent custom by the same builder is very different, and like Jim's uke, does not have a top sound hole, but has small sound holes all the way around the bouts plus a larger one in the cutaway. I've been told it has lots of projection. It's all solid, spalted mango top and flame mango body with spalted mango binding.
This is Michael Kohan in Los Angeles, Beverly Grove near the Beverly Center
9 tenor cutaway ukes, 4 acoustic bass ukes, 12 solid body bass ukes, 14 mini electric bass guitars (Total: 39)
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