Anything is possible - you probably will have to select different string gages to get good intonation.
Also, on mandolins all courses are tuned in unison.
Also, mandolins are steel strings and very short-sustain carved tops, while ukes are nylong strings on a box that, while it doesn't have as much sustain as a guitar, has more sustain than most mandolins.
So, if you're looking to turn a uku into a mando, it can be done but it's not going to be a very good mando.
John