I broke my wrist and elbow on my left arm three years ago in a motorcycle accident. I always played my guitar for Sunday School before then, but couldn't play anything. That's actually what turned me onto the uke. I had a Grizzly uke that I assembled, but just never played. The kids liked singing, so I made it work playing with the uke. I had to hold it weird... kind of like a miniature upright bass, but it worked, and probably helped heal and strengthen my wrist as the doctor was impressed with the healing speed. The elbow healed in average time, but the wrist healed up a bit faster.
Personally, I'd say if you have a soprano, just hold it however you can as long as you aren't hurting yourself, and just try. I couldn't change chords too fast, so I stuck with slower songs, or songs where I transposed to make changing chords a bit easier.
Dan