I find that building with the bridge at the centre of the lower bout (the sweet spot) gives a fuller sound than other bridge positions. By that, I mean stronger mid and bass frequencies. Ukes are strong on high frequencies by their nature, so enhancing the lower frequencies is something I aim for.
A 14 fret neck join with a standard scale length means one of:
1. Use a 'standard' (ie Martin) body shape but move the bridge forward - loses some mids and low frequencies.
2. Modify the shape (flatten the upper bout as in a dreadnaught and widen lower down to keep the same body volume) - this works if you can find a nice shape, maybe something like a Ditson.
3. Reduce the size of the body to keep the shape you like but put the bridge in the sweet spot - the uke will likely be a little quieter and lose some bass frequencies. However, you might compensate for that by deepening the body a little, and also by arching the back quite aggressively (I find this enhances the mids on my own builds).
I'm with Ken Timms on this - put the bridge in the best place and then design everything else around that.