I wish I had one 20 years ago. That is how much I love the uke. Now my Gibson CL-35 deluxe is so lonely.I'll start:
A setup will make or break your first experiences trying to play your new instrument. Factor a setup into the cost of purchasing your first ukulele. Don't assume that, just because you've bought an instrument from a ukulele company, they've set it up before shipping it out to you. (I'm looking at you, Honolua!) Maybe ask, or at the very least, take your new instrument to a local shop for a quick look-see.
After struggling with Bb chord and a few beginner barre chords for several days, it occurred to me that my strings might be too high, so I took the uke to a local guitar shop. Guess what? The strings were set too high. I've just gotten the uke back, and I can now magically play a Bb chord.